Under an EPSRC fellowship programme, our team are exploring the integration of elemental mapping, provided by an ion beam accelerator with “omics”. We are developing new workflows for multimodal elemental and mass spectrometry imaging, and are applying these tools to various biological systems. Here we will show how these new tools may give new insight into the pathogenesis of tuberculosis.
We hare also developing a nanocapillary sampling tool for the analysis of lipids and drugs in single, living cells. We will show how this approach has been used to explore the relationship between anti-TB drug uptake and lipid profiles in single cells.